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he fully-developed spores, and posed the substance to a variety of conditions. He permitted the dried blood to assume the form of dust; wetted this dust, allowed it to dry again, permitted it to remain for an indefinite time in the midst of putrefying matter, and subjected it to various other tests. After keeping the spore-charged blood which had been treated in this fashion for four years, he inoculated a number of mice with it, and found its action as fatal as that of blood fresh from the veins of an animal suffering from splenic fever. There was no single escape from death after inoculation by this deadly _contagium_. Uncounted millions of these spores are developed in the body of every animal which has died of splenic fever, and every spore of these millions is competent to produce the disease. The name of this formidable parasite is Bacillus anthracis. [Footnote: Koch found that to produce its characteristic effects the _contagium_ of splenic fever must enter the blood; the virulently festive spleen of a diseased animal may be eaten with impunity by mice. On the other hand, the disease refuses to be communicated by inoculation to dogs, partridges, or sparrows. In their blood Bacillus anthracis ceases to act as a ferment. Pasteur announced more than six years ago the propagation of the vibrios of the silkworm disease called _flacherie_, both by fission and by spores. He also made some remarkable experiments on the permanence of the _contagium_ in the form of spores. See 'Etudes sur la Maladie des Vers a Soie,' pp. 168 and 256.] Now the very first step towards the extirpation of these _contagia_ is the knowledge of their nature; and the knowledge brought to us by Dr. Koch will render as certain the stamping out of splenic fever as the stoppage of the plague of _pebrine_ by the researches of Pasteur. [Footnote: Surmising that the immunity enjoyed by birds might arise from the heat of their blood, which destroyed the bacillus, Pasteur lowered their temperature artificially, inoculated them, and killed them. He also raised the temperature of guinea-pigs after inoculation, and saved them. It is needless to dwell for a moment on the importance of this experiment.] One small item of statistics will show what this implies. In the single district of Novgorod in Russia, between the years 1867 and 1870, over fifty-six thousand cases of death by splenic fever, among horses, cows, and sheep were recorded. Nor did
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