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-05. The man who gave the greatest impetus to the study of scientific medicine at this time was Bichat, who pointed out that the pathological changes in disease were not so much in organs as in tissues. His studies laid the foundation of modern histology. He separated the chief constituent elements of the body into various tissues possessing definite physical and vital qualities. "Sensibility and contractability are the fundamental qualities of living matter and of the life of our tissues. Thus Bichat substituted for vital forces 'vital properties,' that is to say, a series of vital forces inherent in the different tissues."(11) His "Anatomic Generale," published in 1802, gave an extraordinary stimulus to the study of the finer processes of disease, and his famous "Recherches sur la Vie et sur la Mort" (1800) dealt a death-blow to old iatromechanical and iatrochemical views. His celebrated definition may be quoted: "La vie est l'ensemble des proprietes vitales qui resistent aux proprietes physiques, ou bien la vie est l'ensemble des fonctions qui resistent a la mort." (Life is the sum of the vital properties that withstand the physical properties, or, life is the sum of the functions that withstand death.) Bichat is another pathetic figure in medical history. His meteoric career ended in his thirty-first year: he died a victim of a post-mortem wound infection. At his death, Corvisart wrote Napoleon: "Bichat has just died at the age of thirty. That battlefield on which he fell is one which demands courage and claims many victims. He has advanced the science of medicine. No one at his age has done so much so well." (11) E. Boinet: Les doctrines medicules, leur evolution, Paris, 1907, pp. 85-86. It was a pupil of Corvisart, Rene Theophile Laennec, who laid the foundation of modern clinical medicine. The story of his life is well known. A Breton by birth, he had a hard, up-hill struggle as a young man--a struggle of which we have only recently been made aware by the publication of a charming book by Professor Rouxeau of Nantes--"Laennec avant 1806." Influenced by Corvisart, he began to combine the accurate study of cases in the wards with anatomical investigations in the dead-house. Before Laennec, the examination of a patient had been largely by sense of sight, supplemented by that of touch, as in estimating the degree of fever, or the character of the pulse. Auenbrugger's "Inventum novum" of percussion, r
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