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uction to his "Descent of Man," "Ignorance more frequently begets confidence than does knowledge: it is those who know little and not those who know much who so positively assert that this or that problem will never be solved by science." As far as concerns the two separate limits which Du Bois-Reymond fixes for human knowledge, in my opinion they are undoubtedly identical. The problem of the origin and nature of consciousness is only a special case of the general problem of the connection of matter and force. Du Bois-Reymond himself indicates that this is possible at the close of his paper; for he says, "Finally, the question arises whether the two limitations to our natural knowledge may not perhaps be identical; that is to say, whether if we could conceive of the true essence of matter and force, we should not also understand how the substance which lies at their root can, under certain given conditions, feel, desire, and think. This conception is, no doubt, the simplest, and according to admitted principles of inquiry it is to be preferred to that other which it confutes, and according to which, as has been said, the world appears doubly incomprehensible. But it is in the very nature of things that we cannot on this point come to any clear conclusion, and all further words on the subject are idle--and so, 'Ignorabimus.'" The light way in which Du Bois-Reymond here passes over the most important part of his subject is truly surprising; as if it were ultimately indifferent whether we have before us one single insoluble fundamental problem or two quite different ones; and as if mature reflection did not lead to the conviction that, in fact, the second problem is only a special case of the first general problem. I, for my part, cannot conceive of them in any other relation; I think, too, that all further words are by no means superfluous, but on the contrary conduce to a very strong conviction of the unity of the problem. That Du Bois-Reymond also has not come to any clear conclusion on this point lies, not alone in the "nature of things," but, as in Virchow's case, in the nature of the investigator himself; in his lack of knowledge of the history of evolution, and in his neglect of those comparative and genetic methods of study, without which, in my opinion, not even an approximate solution of this highest and most difficult question is to be looked for. Nothing appears to me to be of more importance for the mechan
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