+-----------+------------+----------+-------+-------+-----------+------+
| .| | | +-------+-----------+------+
M .F F F | | +------+
| .| | | MB F Died in No
Died Grandmother | | | Childbed Family
aet. .| | +-----------+ +----+---
70 .| +------+ |had family | |
.| | | |but history| |
.| MB MB |not known | MB
.|
.|
.|.............................
+-----+----------+------------+------------+------------+-------------+
| | | | |. | |
| | | | |. | |
M M M MB F. F F
| |. | |
| Mother +--+--+---+--+--+ |
+----+ |. | | | | | | |
| | |. M M MB F F F |
M F |. |
Not Married |. +---+---+---+---+
|. | | | | |
|. MB M MB M M
.............|.
+-----+-----+-----+-----+-----+
| .| .| | | |
| .|* .|* | | |
M MB MB F F F

F = Females. M = Males (not bleeders). MB = Males (bleeders)

** the patients observed by the authors. The dotted line shows the
transmission of the disease to our patients through four
generations.

The disease is met with in boys who are otherwise healthy, and usually
manifests itself during the first few years of life. In rare instances
profuse haemorrhage takes place when the umbilical cord separates. As a
rule the first evidence is the occurrence of long-continued and
uncontrollable bleeding from a comparatively slight injury, such as the
scratch of a pin, the extraction of a tooth, or after the operation of